The use of Serrapeptase as an anti-inflammatory agent in IC is very well indicated.  However its benefits include so much more than just reducing inflammation in the bladder.  Because it dissolves fibrous tissue and cleans the blood vessels of atherosclerotic plaque, it increases blood flood to the entire body and improves overall health.  There are a few cautions however.  People that are using strong blood thinners need to discuss addition of this enzyme with their medical professional and monitor blood clotting factors.  Individuals with serious lung problems should use caution as mucus secretions are thinned5.

 DOSAGE/USAGE:  One daily, 80,000 SPU’s on an empty stomach, indefinitely.

The best time to take this enzyme is a little before starting your day as that is when your stomach is the emptiest.  The general rule is a half hour before eating or a full two hours after.  Dosage is in serratiopeptidase units or SPU’s with a usual dose of 80,000 per capsule.  It is important to understand that it might take weeks or even months before an improvement in symptoms is noticed.         



1.       Serrapeptase: The Natural Anti-Inflammatory, FL, Life Extension Magazine, LE Publications:1-5, Sept 2003.

2.       Serrapeptase: The Natural Anti-Inflammatory, FL, Life Extension Magazine, LE Publications:1-5, Sept 2003.

3.       Redfern, R: The Miracle Enzyme is Serrapeptase, UK, Naturally Healthy Publications:34,2006-2009.

4.       Fraser, Ivan: The Second Gift from Silkworm is Serrapeptase, Good Health Naturally - excerpt:4.

5.       Serrapeptase: The Natural Anti-Inflammatory, FL, Life Extension Magazine, LE Publications:1-5, Sept 2003.


Any and all information provided by Diana Brady, Natural Healing, LLC, its agents, employees, merchants, sponsors and third party content providers is for information purposes only.  It is not intended to substitute for advice given by a physician, or other licensed health care professional.   Always consult with your own health care provider.  Information and statements regarding dietary supplements are based upon anecdotal evidence only and have not been evaluated by the food and drug administration.  This information is not intended to diagnose, treat, cure or prevent any disease or health condition.  Reliance on any materials presented shall be at your sole risk.


Painful Bladder Syndrome


The Use of Serrapeptase Enzyme to treat Inflammation in Interstitial Cystitis (IC)

by Diana Brady, MA, CNC -  author of IC Naturally

 Serrapeptase Enzyme

The chronic inflammation of an IC bladder causes overall discomfort, pain and tissue damage while providing an ideal environment for yeast, bacteria and viruses to grow exponentially.  Anti-inflammatory medications are routinely used by people with IC to alleviate bladder inflammation and pain.  The typical anti-inflammatory medications include aspirin, ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs).  Although providing some relief, NSAIDs, are known to cause stomach distress, ulcers and even stomach bleeding.  Serrapeptase is a naturally occurring anti-inflammatory enzyme that has even more benefits than the average NSAID without any of the negative side effects1. 

 Enzymes are biologically active proteins responsible for every chemical reaction and normal activity of the body’s cells, tissues, fluids and organs.  They work in very specific ways depending upon their biological function.  Serrapeptase belongs to the group of enzymes defined as proteolytic, that is protein digesting.  This specific enzyme reduces inflammation in several ways.  First it reduces inflammation by thinning (dissolving) the fluids formed from injury, facilitating drainage of this fluid and thereby aiding in tissue repair.  Second it helps alleviate pain by inhibiting the release of pain causing molecules, bradykinin.  Lastly it breaks down the protein by-products of blood coagulation and inflammation called fibrin.  Fibrin is the protein that develops into scar tissue if an inflammatory process is not resolved.  Significantly Serrapeptase is able to dissolve fibrin and other dead or damaged tissue without harming living tissue2.

 Serrapeptase has been used therapeutically for over 25 years with at least 50 clinical studies performed primarily in Europe and Asia.  Because the enzyme digests or dissolves all nonliving tissue, including blood clots, cysts, arterial plaque and waste products of inflammatory processes, it is used to treat a variety of conditions.  These conditions include cystitis, fibrocystic breasts, atherosclerosis, chronic sinusitis, traumatic tissue injury, post-operative inflammation, excessive lung secretions, blood clots in the legs, ankle swelling, carpal tunnel syndrome and many others3,4. 


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